Abstract
Objective: To estimate the prevalence of metabolic syndrome and identify the associated factors in postmenopausal women.
Materials and methods: An analytical cross-sectional study was conducted. A total of 627 women aged 40 years or older, diagnosed with menopause and not using hormone therapy, residing in the department of Quindío (Colombia) between 2013 and 2023, were included. Metabolic syndrome was defined according to the criteria of the International Diabetes Federation. Descriptive and bivariate analyses were performed, and measures of association were estimated using odds ratios (OR) with 95% confidence intervals (CI).
Results: The study included 627 postmenopausal women with a mean age of 57 ± 8.64 years and a mean age at menopause onset of 49 ± 3.52 years. The prevalence of metabolic syndrome was 74.16% (95% CI: 70.73–77.59). Metabolic syndrome was strongly associated with obesity (adjusted OR [ORa]: 9.00; 95% CI: 5.00–16.00), a history of gestational diabetes (ORa: 5.50; 95% CI: 2.50–12.00), and alcohol consumption (ORa: 4.50; 95% CI: 2.80–7.20). In contrast, a higher educational level (ORa: 0.45; 95% CI: 0.25–0.82) and adherence to a healthy diet (ORa: 0.60; 95% CI: 0.40–0.90) were inversely associated with metabolic syndrome.
Conclusions: Metabolic syndrome was highly prevalent among postmenopausal women. Key associated factors included alcohol consumption, smoking, and a history of gestational diabetes, while a higher educational attainment and adherence to a healthy diet were inversely associated. These results underscore the importance of implementing comprehensive cardiovascular prevention strategies for this population. Nevertheless, further analytical studies are needed to clarify causal relationships and inform targeted interventions.
References
Saklayen MG. The global epidemic of the metabolic syndrome. Curr Hypertens Rep. 2018;20(2):12. https://doi.org/10.1007/s11906-018-0812-z
Rochlani Y, Pothineni NV, Kovelamudi S, Mehta JL. Metabolic syndrome: Pathophysiology, management, and modulation by natural compounds. Ther Adv Cardiovasc Dis. 2017;11(8):215-225. https://doi.org/10.1177/1753944717711379
Grundy SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol. 2008;28(4):629-636. https://doi.org/10.1161/ATVBAHA.107.151092
Márquez-Sandoval F, Macedo-Ojeda G, Viramontes-Hörner D, Fernández Ballart JD, Salas Salvadó J, Vizmanos B. The prevalence of metabolic syndrome in Latin America: A systematic review. Public Health Nutr. 2011;14(10):1702-1713. https://doi.org/10.1017/S1368980010003320
Royer M, Castelo-Branco C, Blümel JE, Chedraui PA, Danckers L, Bencosme A, et al. The US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III): prevalence of the metabolic syndrome in postmenopausal Latin American women. Climacteric. 2007;10(2):164-170. https://doi.org/10.1080/13697130701258895
Villegas-Abrill CB, Vidal-Espinoza R, Gomez-Campos R, Ibañez-Quispe V, Mendoza-Mollocondo C, Cuentas-Yupanqui SR, et al. Diagnostic criteria for metabolic syndrome in high-altitude regions: A systematic review. Medicina (Kaunas). 2022;58(3):451. https://doi.org/10.3390/medicina58030451
Vrbaški D, Vrbaški M, Kupusinac A, Ivanovi? D, Stoki? E, Iveti? D, et al. Methods for algorithmic diagnosis of metabolic syndrome. Artif Intell Med. 2019;101:101708. https://doi.org/10.1016/j.artmed.2019.101708
Rus M, Crisan S, Andronie-Cioara FL, Indries M, Marian P, Pobirci OL, et al. Prevalence and Risk factors of metabolic syndrome: A prospective study on cardiovascular health. Medicina (Kaunas). 2023;59(10):1711. https://doi.org/10.3390/medicina59101711
Jurcut R. Factorii de risccardiovasculari. In: Ginghina C., editor. Mic Tratat de Cardiologie. 2nd ed. Bucharest, Romania: Editura Academiei Romane; 2017. p. 175–189.
Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab. 2003;88(6):2404-2411. https://doi.org/10.1210/jc.2003-030242
Janssen I, Powell LH, Crawford S, Lasley B, Sutton-Tyrrell K. Menopause and the metabolic syndrome: the Study of Women's Health Across the Nation. Arch Intern Med. 2008;168(14):1568-1575. https://doi.org/10.1001/archinte.168.14.1568
Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB. The metabolic syndrome: Prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med. 2003;163(4):427-436. https://doi.org/10.1001/archinte.163.4.427
Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P, et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol. 2010;56(14):1113-1132. https://doi.org/10.1016/j.jacc.2010.05.034 .
Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D. Metabolic syndrome and risk of cancer: A systematic review and meta-analysis. Diabetes Care. 2012;35(11):2402-2411. https://doi.org/10.2337/dc12-0336
Beltrán-Sánchez H, Harhay MO, Harhay MM, McElligott S. Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999-2010. J Am Coll Cardiol. 2013;62(8):697-703. https://doi.org/10.1016/j.jacc.2013.05.064
Takahashi TA, Johnson KM. Menopause. Med Clin North Am. 2015;99(3):521-534. https://doi.org/10.1016/j.mcna.2015.01.006
Burger HG, Hale GE, Robertson DM, Dennerstein L. A review of hormonal changes during the menopausal transition: Focus on findings from the Melbourne Women's Midlife Health Project. Hum Reprod Update. 2007;13(6):559-565. https://doi.org/10.1093/humupd/dmm020
Randolph JF Jr, Zheng H, Sowers MR, Crandall C, Crawford S, Gold EB, et al. Change in follicle-stimulating hormone and estradiol across the menopausal transition: Effect of age at the final menstrual period. J Clin Endocrinol Metab. 2011;96(3):746-754. https://doi.org/10.1210/jc.2010-1746
Urina-Jassir D, Urina Triana M, Mantilla Moron M, Urina Triana M, Galeano Muñoz Luisa. La prevalencia del síndrome metabólico en mujeres postmenopáusicas. Rev Latinoam Hipertens. 2018;13(4):384–389.
Alberti KG, Zimmet P, Shaw J. Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006;23(5):469-480. https://doi.org/10.1111/j.1464-5491.2006.01858.x
World Health Organization (WHO). Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253.
Mancia G, Kreutz R, Brunström M, Burnier M, Grassi G, Januszewicz A, et al. 2023 ESH Guidelines for the management of arterial hypertension the task force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens. 2023;41(12):1874-2071. https://doi.org/10.1097/HJH.0000000000003480
Marchi R, Dell'Agnolo CM, Lopes TCR, Gravena AAF, Demitto MO, Brischiliari SCR, et al. Prevalence of metabolic syndrome in pre- and postmenopausal women. Arch Endocrinol Metab. 2017;61(2):160-166. https://doi.org/10.1590/2359-3997000000253
Ruan X, Jin J, Hua L, Liu Y, Wang J, Liu S. The prevalence of metabolic syndrome in Chinese postmenopausal women and the optimum body composition indices to predict it. Menopause. 2010;17(3):566-570. https://doi.org/10.1097/gme.0b013e3181c8f4e1
Raczkiewicz D, Owoc A, Wierzbi?ska-St?pniak A, Bojar I. Metabolic syndrome in peri - and postmenopausal women performing intellectual work. Ann Agric Environ Med. 2018;25(4):610-615. https://doi.org/10.26444/aaem/74451
Arthur FK, Adu-Frimpong M, Osei-Yeboah J, Mensah FO, Owusu L. The prevalence of metabolic syndrome and its predominant components among pre-and postmenopausal Ghanaian women. BMC Res Notes. 2013;6:446. https://doi.org/10.1186/1756-0500-6-446
de Carvalho Vidigal F, Bressan J, Babio N, Salas-Salvadó J. Prevalence of metabolic syndrome in Brazilian adults: A systematic review. BMC Public Health. 2013;13:1198. https://doi.org/10.1186/1471-2458-13-1198
Dutra ES, de Carvalho KM, Miyazaki E, Hamann EM, Ito MK. Metabolic syndrome in central Brazil: Prevalence and correlates in the adult population. Diabetol Metab Syndr. 2012;4(1):20. https://doi.org/10.1186/1758-5996-4-20
Salsberry PJ, Corwin E, Reagan PB. A complex web of risks for metabolic syndrome: Race/ethnicity, economics, and gender. Am J Prev Med. 2007;33(2):114-120. https://doi.org/10.1016/j.amepre.2007.03.017
Loucks EB, Rehkopf DH, Thurston RC, Kawachi I. Socioeconomic disparities in metabolic syndrome differ by gender: evidence from NHANES III. Ann Epidemiol. 2007;17(1):19-26. https://doi.org/10.1016/j.annepidem.2006.07.002
Kim MH, Kim MK, Choi BY, Shin YJ. Educational disparities in the metabolic syndrome in a rapidly changing society--the case of South Korea. Int J Epidemiol. 2005;34(6):1266-1273. https://doi.org/10.1093/ije/dyi175
Marbou WJT, Kuete V. Prevalence of metabolic syndrome and its components in bamboutos division's adults, west region of Cameroon. Biomed Res Int. 2019;2019:9676984. https://doi.org/10.1155/2019/9676984
El Brini O, Akhouayri O, Gamal A, Mesfioui A, Benazzouz B. Prevalence of metabolic syndrome and its components based on a harmonious definition among adults in Morocco. Diabetes Metab Syndr Obes. 2014;7:341-346. https://doi.org/10.2147/DMSO.S61245

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