Abstract
John F. Kennedy had many medical conditions during his lifetime. Addison disease was diagnosed when Kennedy was 30 years of age, and he was found to have hypothyroidism when he was a senator. The coexistence of autoimmune adrenal disease and hypothyroidism is consistent with APS
2.
Possibly because of autoimmune disease but probably as a result of long-term steroid
replacement therapy, Kennedy's endocrinologist prescribed treatment with testosterone, and this may have been initiated during the 1960 presidential campaign. Despite his many medical
conditions as well as his recurrent back problems, John F. Kennedy managed to convey an image of health and vigor that masked the true state of his health to the U.S. public. In this narrative review
we mention marginally the autopsy that followed his assassination.
References
Hoenig LJ, Burgdorf WH. President Kennedy's White House tan. JAMA Dermatol. 2013 May;149(5):597.
Jacome-Roca A. Historia de las Hormonas. Acad Nac Med Col. 2008. Pp 39-40
Cohen SG. Asthma among the famous. John F. Kennedy (1917-1963) 35th President of the United States. Allergy Asthma Proc. 1998;19(5):312-7.
Lacayo R. How sick was JFK? Time. 2002 Dec 2;160(23):46-7.
Gomez CF, Crispell KR. John F Kennedy and medical research. J Med Biogr 1994;2(2)103-120
Mandel LR. Endocrine and autoimmune aspects of the health history of John F. Kennedy. Ann Intern Med. 2009; 151 (5): 350-4
Addison T. On the Constitutional and Local Effects of Disease of Suprarenal Capsules. London: Dhigley, 1855.
Loughlin KR. John F Kennedy and his adrenal diseaqse . Urology. 2002;59(1):165-9.
Bernal-Misrachi M. Corteza suprarrenal. En Fisiología Endocrina 4ª. Edición, Bogotá, 2017 Editorial Manual Moderno. Pp. 122-141
Giglio JN. Growing up Kennedy: the role of medical ailments in the life of JFK, 1920-1957. J Fam Hist. 2006;31(4):358-85.
Michels AW, Eisenbarth GS. Autoimmune polyendocrine syndrome type 1 (APS-1) as a model for understanding autoimmune polyendocrine syndrome type 2 (APS-2). J Intern Med. 2009; 265(5):530-40.
Maclaren NK, Riley WJ. Inherited susceptibility to autoimmune Addison's disease is linked to human leukocyte antigens-DR3 and/or DR4, except when associated with type I autoimmune polyglandular syndrome. J Clin Endocrinol Metab. 1986 Mar;62(3):455-9.
Macchia D, Lippi D, Bianucci R, Donell S. President John F Kennedy's medical history: coeliac disease and autoimmune polyglandular syndrome type 2. Postgrad Med J. 2020 Sep;96(1139):543-549
Schatz DA, Winter WE. Autoimmune polyglandular syndrome. II: Clinical syndrome and treatment. Endocrinol Metab Clin North Am. 2002; 31:339-52.
Majeroni BA, Patel P. Autoimmune polyglandular syndrome, type II. Am Fam Physician. 2007; 75:667-70.
Robles DT, Fain PR, Gottlieb PA, Eisenbarth GS. The genetics of autoimmune polyendocrine syndrome type II. Endocrinol Metab Clin North Am. 2002; 31:353-68
Falorni A, Laureti S, Santeusanio F. Autoantibodies in autoimmune polyendocrine syndrome type II. Endocrinol Metab Clin North Am. 2002; 31:369-89
Neufeld M, Maclaren N , Blizzard R. Autoimmune Polyglandular Syndromes. Pediatr Ann. 1980; 9:154-62.
Barton SH , Murray JA . Coeliac Disease and bowel autoimmunity and in other organs. Gastroenterol Clin North Am. 2008; 37:411-28
Caturegli P, Newschaffer C , Olivi A, Pomper MG, Burger PC , Rose NR. Autoimmune hypophysitis. Endocr Rev. 2005; 26:599.
Jacome A. Los 17-cetosteroides. Rev Col Endocrinol Diab & Metab. 1980.12(2): 119-122.
Nicholas JA, Burstein CL, Umberger CJ, Wilson PD. Management of adrenocortical insufficiency during surgery. AMA Arch Surg. 1955; 71:737-42.
Nichols J. President Kennedy's adrenals. JAMA. 1967; 10;201(2):115-6.
Kurtzman NA, Nichols J. President Kennedy and Addison's disease. JAMA. 1967. 25; 201(13):1052.
Lattimer JK. Observations based on a review of the autopsy photographs, x-rays, and related materials of the late President John F. Kennedy. Med Times. 1972 Jun;100(6):33-64.
O'Leary P. Letter to Joseph P. Kennedy, 16 August 1940. Joseph P. Kennedy Papers. John F. Kennedy Health File, “Correspondence 1940–1942” folder, box 21. John F. Kennedy Presidential Library & Museum, Boston, MA.
Pinals RS, Hasset AL. Reconceptualizing John F. Kennedy’s low back pain. Reg Anesth Pain Med. 2013; 38 (5):442-6
Travell J, Cohen E. Letter to Senator John F. Kennedy, 5 July 1960, Dr. Janet Travell, Lists and Correspondence, box 45. John F. Kennedy Presidential Library & Museum Boston, MA.
Reeves R. President Kennedy: Profile of Power. New York: Simon & Schuster; 1993:42-4.

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