Calciferoles: las hormonas del momento
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vitamin D
antirachitic factor
vitamin D receptor
cod liver oil

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Jácome, A. (2019). Calciferoles: las hormonas del momento. Revista Colombiana De Endocrinología, Diabetes &Amp; Metabolismo, 6(4), 318–324.


Discovery of calciferols was done after rachitism was recognized and studied. Herodotus link bone strength to sun light. Rachitism epidemics affected England and Scotland during second decade of the seventeenth century, making Glisson to describe the disease in 1650. In 1918, Mellamby discovered the cause, worried about the UK epidemics. Following McCollum ideas, he thought rachitism would be a nutritional deficiency. He examined scottish diet, and fed dogs with oat flour, putting them away from sun light. Once rachitic, they were cured with cod liver oil. He thought of vitamin A as the cause of the disease. McCollum then found in 1922 a second lipid-soluble factor responsible of bone calcification and named it vitamin D, as the fourth vitamin. Calciferols study showed that they were eminently diet compounds, essentials vitamins. They were later studied as hormones (DeLucca) but discovery of its receptor widened his action and is now regarded as an immunomodulator.
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