Disfunción tiroidea posexposición a medio de contraste yodado
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Keywords

Disfunción tiroidea
medio de contraste yodado
hipertiroidismo
hipotiroidismo
Thyroid dysfunction
iodine contrast medium
hyperthyroidism
hypothyroidism

How to Cite

García Rincón, C. I., Becerra Salazar, L. Y., Moreno Gómez, G. A., & Arenas Quintero, H. M. (2017). Disfunción tiroidea posexposición a medio de contraste yodado. Revista Endocrino, 2(1), 5–9. https://doi.org/10.53853/encr.2.1.64

Abstract

La exposición a cantidades excesivas de yodo bloquea la actividad de la enzima peroxidasa tiroidea (TPO), un fenómeno conocido como efecto de Wolff-Chaikoff. Clínicamente, éste puede llevar a hipotiroidismo. Por el contrario, cuando un tirocito contiene valores bajos de yodo y es expuesto a elevadas concentraciones del mismo, aumenta de forma significativa la producción de hormona tiroidea, llevando frecuentemente a hipertiroidismo clínico y bioquímico, fenómeno conocido como efecto de Jod-Basedow. Tanto el hiper como el hipotiroidismo aumentan el riesgo de enfermedad arterial coronaria, miopatía ventricular izquierda, anormalidades electrofisiológicas, además de incrementar la mortalidad cardiovascular y por todas las causas.

Abstract
Exposure to excessive amounts of iodine blocks the activity of the enzyme thyroid peroxidase (TPO), a phenomenon known as Wolf-Chaikoff effect. Clinically, this effect can lead to hypothyroidism. On the other hand, when thyrocites have low iodine levels and are exposed to a high iodine concentration, they increase significantly their production of thyroid hormone thus leading to hyperthyroidism, a phenomenon known as Jod-Basedow effect. Both hypothyroidism and hyperthyroidism increase the risk of coronary artery disease, left cardiomyopathy, electrophysiological abnormalities, and all-cause mortality.

https://doi.org/10.53853/encr.2.1.64
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