Tuberculosis y vitamina D: una relación intrigante

  • C. F. Ramírez Ramos Universidad Surcolombiana
  • J. F. Salamanca-Montilla Universidad Surcolombiana
  • S. Correa Universidad Surcolombiana
  • J. M. Torres-Restrepo Universidad Surcolombiana
  • D. A. Ramírez-Méndez Universidad Surcolombiana
  • J. D. Rivera-Marín
  • A. Pinzón-Tovar Universidad Surcolombiana
  • G. Lastra-González Universidad Surcolombiana

Resumen

La tuberculosis permanece como la enfermedad infecciosa que más muertes ha causado a lo largo de la historia de la existencia humana, sin poderse aún lograr su control. En años recientes ha emergido un cúmulo importante de evidencia clínica acerca de la función de la vitamina D (calcitriol o 1,25 hidroxivitamina D) en un papel que va más allá de la homeostasis del calcio. Su papel en el sistema inmunológico es muy interesante vinculando su déficit como un factor de riesgo contribuyente y así mismo fisiopatológico en un gran número de enfermedades autoinmunes e infecciosas. Dentro de éstas se destaca la tuberculosis, enfermedad endémica en nuestro país y en la cual el déficit de dicho compuesto (vitamina D) crea un factor de riesgo para desarrollar esta enfermedad en su forma activa.

Presentamos una revisión detallada de los estudios que explican el papel de la vitamina D en la susceptibilidad para el desarrollo de tuberculosis y los resultados de los estudios clínicos de suplencia de la misma publicados a la fecha.

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Biografía del autor

##submission.authorWithAffiliation##

Semillero de investigación en medicina interna -SIMI, grupo de investigación MI-Dneuropsy, Universidad Surcolombiana, Neiva, Huila.

Residente de tercer año de medicina interna, Universidad Surcolombiana, Neiva, Huila.

##submission.authorWithAffiliation##

Semillero de investigación en medicina interna -SIMI, grupo de investigación MI-Dneuropsy, Universidad Surcolombiana, Neiva, Huila.

Residente de tercer año de medicina interna, Universidad Surcolombiana, Neiva, Huila.

##submission.authorWithAffiliation##

Semillero de investigación en medicina interna -SIMI, grupo de investigación MI-Dneuropsy, Universidad Surcolombiana, Neiva, Huila.

Médico Universidad Surcolombiana, Neiva, Huila

##submission.authorWithAffiliation##

Semillero de investigación en medicina interna -SIMI, grupo de investigación MI-Dneuropsy, Universidad Surcolombiana, Neiva, Huila.

Médico Universidad Surcolombiana, Neiva, Huila.

##submission.authorWithAffiliation##

Semillero de investigación en medicina interna -SIMI, grupo de investigación MI-Dneuropsy, Universidad Surcolombiana, Neiva, Huila.

Médico Universidad Surcolombiana, Neiva, Huila.

J. D. Rivera-Marín

Semillero de investigación en medicina interna -SIMI, grupo de investigación MI-Dneuropsy, Universidad Surcolombiana, Neiva, Huila.

Médico rural de investigación, Hospital Universitario Hernando Moncaleano Perdomo, Neiva, Huila.

##submission.authorWithAffiliation##

Semillero de investigación en medicina interna -SIMI, grupo de investigación MI-Dneuropsy, Universidad Surcolombiana, Neiva, Huila.

Médico internista endocrinólogo, coordinador de la clínica de heridas y trastornos metabólicos, Hospital Universitario Hernando Moncaleano Perdomo, Neiva, Huila. Director científico ENDHO Colombia.

##submission.authorWithAffiliation##

Semillero de investigación en medicina interna -SIMI, grupo de investigación MI-Dneuropsy, Universidad Surcolombiana, Neiva, Huila.

Médico internista neumólogo, jefe del servicio de neumología, Hospital Universitario Hernando Moncaleano Perdomo. Jefe departamento de medicina interna, Universidad Surcolombiana, Neiva, Huila.

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Publicado
2019-06-17
##submission.howToCite##
RAMÍREZ RAMOS, C. F. et al. Tuberculosis y vitamina D: una relación intrigante. Revista Colombiana de Endocrinología, Diabetes & Metabolismo, [S.l.], v. 6, n. 2, p. 114-120, jun. 2019. ISSN 2389-9786. Disponible en: <http://www.revistaendocrino.org/index.php/rcedm/article/view/487>. Fecha de acceso: 20 sep. 2019
Sección
Articulos de Revisión