Refractory Hypokalemia as a Clinical Manifestation of Ectopic Cushing Syndrome: A Report of Two Cases and a Review of the Literature
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Keywords

Cushing syndrome
ectopic ACTH secretion
hypocalemia
neuro endocrine tumor
metabolic alcalosis

How to Cite

Coronel Restrepo, N., Mejía Zuluaga, M., Aristizabal, N., & Torres Grajales, J. L. (2019). Refractory Hypokalemia as a Clinical Manifestation of Ectopic Cushing Syndrome: A Report of Two Cases and a Review of the Literature. Revista Endocrino, 6(1), 42–50. https://doi.org/10.53853/encr.6.1.467

Abstract

Cushing’s syndrome (CS) is a set of signs and symptoms caused by the excess of free cortisol in the plasma. Its clinical manifestations are multiple and sometimes not very specific, making its clinical diagnosis difficult. The confirmation of hypercortisolism is a thorough out process that must be done in order to obtain an adequate and accurate diagnosis. The following are two cases of cancer patients whose paraneoplastic clinical manifestation, due to ectopic adrenocorticotropic hormone (ACTH) secretion and associated cushing syndrom, was a severe hypokalemia refractory to conventional treatment. Following the approach presented in the different endocrinology societies, a diagnostic flow chart of patients with hypokalemia is presented and an updated review of the literature regarding ectopic CS.

https://doi.org/10.53853/encr.6.1.467
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